Abstract
GPER-1 acts as a tumor suppressor in ovarian cancer
Highlights
Ovarian cancer is a common neoplasm in Western countries and more than 70% of all diagnoses are in advanced stage [1,2]
G-protein-coupled estrogen receptor-1 (GPER-1) expression was significantly lower in ovarian cancer tissue than in benign and low-malignant ovarian tumors
GPER-1 expression was observed in SKOV-3 and OVCAR-3 ovarian cancer cell lines
Summary
Ovarian cancer is a common neoplasm in Western countries and more than 70% of all diagnoses are in advanced stage [1,2]. Smith and co-workers have shown in 89 ovarian cancer patients that GPER-1 expression is associated with poor survival [13]. Kolkova and co-workers have not found any correlation between GPER-1 expression and survival of 152 patients with ovarian cancer [14]. A third research group has found that GPER-1 expression predicts lower survival of 150 ovarian cancer patients only by co-expression with epidermal growth factor receptor (EGFR) [15]. In vitro studies provide controversial data regarding GPER-1 effect on cell growth [16], adding confusion to the role of GPER-1 in ovarian cancer. It is known that the new membrane-bound estrogen receptor GPER-1 acts suppressive in breast cancer cells and its expression decreases during disease progression.
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