GPCR Protein Feature Representation using Discrete Wavelet Transform and Particle Swarm Optimisation Algorithm

Abstract

Features play an important role in representing classes in the hierarchy structure, and using unsuitable features will affect classification performance. The discrete wavelet transform (DWT) approach provides the ability to create the appropriate features to represent data. DWT can produce global and local features using different wavelet families and decomposition levels. These two parameters are essential to obtain a suitable representation for classes in the hierarchy structure. This study proposes using a particle swarm optimisation (PSO) algorithm to select the suitable wavelet family and decomposition level for G-protein coupled receptor (GPCR) hierarchical class representation. The results indicate that the PSO algorithm mostly selects Biorthogonal wavelets and decomposition level 2 to represent GPCR protein. Concerning the performance, the proposed method achieved an accuracy of 97.9%, 85.9%, and 77.5% at the family, subfamily, and sub-subfamily levels, respectively.