Abstract
Recently, a five-center collaborative study1 reported that genetic variations of glypican 5 (GPC5) may significantly contribute to an increased risk of lung cancer in never smokers. GPC5 gene-expression levels in normal lung tissues were found significantly lower in individuals who carry high-risk alleles, and the GPC5 expression level in adenocarcinoma tissue was significantly lower than in matched normal lung tissue. Reduction of expression of GPC5 may lead to the development of lung cancer, suggesting that this gene normally functions as a tumor suppressor.
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