Abstract
Skeletal muscle wasting and impaired muscle function in response to mechanical ventilation (MV), immobilization (IM) and various pharmacological treatments in intensive care unit (ICU) patients are clinically challenging partly due to the poorly understood intricate cellular and molecular networks and partly due to the unavailability of an animal model mimicking this condition in ICU patients. By employing a unique porcine model mimicking the conditions in the ICU with long-term mechanical ventilation and immobilization and exposed to various combinations of agents, i.e., pharmacological neuromuscular blockade (NMBA), corticosteroids (CS) and/or sepsis we have analyzed the expression profiles and physiological parameters in the muscle biopsies taken from the m.
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