Abstract
Degeneration of neurons and astrocytes mediated by soluble viral proteins and neurotoxins is an important factor involved in the pathogenesis of HAD. We investigated whether different soluble HIV-1 envelope proteins (X4, R5 and R5X4 tropic HIV-1 gp120) induced apoptosis in neurons and astrocytes. Here we show that this effect is influenced by the structure and chemokine receptor tropism of the different gp120 isoforms.
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