Abstract
Acute gout is the inflammatory reaction provoked by monosodium urate (MSU) crystals when they form within a joint. It affects mainly males, due to their physiologically higher serum uric acid (UA) levels, and there is epidemiological evidence that the prevalence of gout and hyperuricemia is on the increase in western and Asian populations in both sexes and with aging. It is estimated that the prevalence of gout increased by 60 % in those aged over 65 and doubled in the population over 75 years of age between 1990 and 1999 [1]. The prevalence is estimated to be 1.4 % in the adult population in the UK, with a peak of over 7 % in men aged over 75 years old [2]. In addition, a strong association between hyperuricemia and the metabolic syndrome (see chapter “Metabolic syndrome”) was observed. Potential explanations include lifestyle and dietary changes brought about by increasing prosperity and increased life expectancy of the population, not to mention the coexistence of multiple medical comorbidities and their treatments (i.e., hypertensive agents) that favor hyperuricemia in the elderly.KeywordsUric AcidXanthine OxidaseSerum UrateAcute GoutXanthine Oxidase InhibitorThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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