Abstract
ABSTRACTAimGoshajinkigan (GJG) improves hyperesthesia and hypoesthesia in diabetic peripheral neuropathy (DPN) by increasing nitric oxide (NO) production. In this study, we investigated the involvement of NO in the vasodilatory effect of GJG in peripheral capillaries to clarify the mechanism related to DPN symptom improvement.MethodsGJG was orally administered to non‐diabetic and streptozotocin (STZ)‐induced diabetic male mice. Auricular venule and arteriole diameters were measured by video capillaroscopy. The mice were pretreated with NG‐nitro‐L‐arginine methyl ester (L‐NAME) to assess NO involvement.ResultsGJG increased venule and arteriole diameters in both non‐diabetic and diabetic mice. L‐NAME pretreatment inhibited GJG‐induced increases in capillary diameter.ConclusionThe direct vasodilatory effect of GJG in peripheral arterioles and venules involved increased NO production.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
