Goserelin combined with marvelon in treatment of patients with endometriosis

Abstract

Objective To investigate the effect of goserelin combined with marvelon in treatment of endometriosis(EM)and its effect on estrogen levels. Methods 120 EM patients were randomly divided into the observation group(60 cases)and the control group(60 cases)according to the digital table. Two groups underwent laparoscopy. 3.6 mg sustained release goserelin was injected subcutaneously from the anterior abdominal wall once every four weeks on the first time of menses recovery. The treatment continued during the following six months. The observation group were treated with marvelon on the basis of this, 1 tablet each day, 21 days of continuous treatment and then began to take medicine on the 5th day of the next menstruation during the following six months. The two groups were followed up for two years. The level of luteinizing hormone(LH), follicle-stimulating hormone(FSH)and estradiol(E2), the cumulative pregnancy rate, recurrence rate and peri menopausal status of the two groups were observed before and after treatment. Results The total effective rate was 96.67% and 83.33% respectively for the observation group and the control group. The difference had statistical significance(P 0.05). Conclusion Goserelin combined with marvelon can effectively improve the effect of laparoscopic surgery in treatment of endometriosis, lower estrogen level, improve patients' pregnancy rate, and reduce the recurrence rate. Key words: Goserelin; Marvelon; Endometriosis; Estrogen