Abstract
A novel catalyst system has been indentified for addressing the long-standing issue of Z/E stereoselectivity in palladium-catalyzed exo-mode cyclization reactions of allenes bearing a nucleophilic functionality with organic halides or their equivalents. The readily accessible, sterically hindered monophosphine ligand Gorlos-Phos·HBF4 imparts a remarkable stereocontrolling ability with broad generality under Pd catalysis.
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