Abstract
In this issue of the Journal, Pedchenko et al.1 increase our understanding of the pathogenesis of two forms of antibody-mediated glomerulonephritis. One, Goodpasture's disease, is an organ-specific autoimmune disease that is mediated by anti–glomerular basement membrane (anti-GBM) antibodies and has a pathology characterized by crescentic glomerulonephritis with linear immunofluorescent staining for IgG on the GBM. It typically presents as acute renal failure caused by a rapidly progressive glomerulonephritis, often accompanied by pulmonary hemorrhage, that may be life-threatening.The other form of glomerulonephritis, so-called Alport's post-transplantation nephritis, occurs in a small proportion of patients with Alport's syndrome after kidney transplantation. Alport's . . .
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