Good syndrome and polymyositis

Abstract

Good syndrome (GS) was first described by Dr Robert Good in 1954 in an adult patient with thymoma and immunodeficiency. [1] Good R.A. Agammaglobulinaemia—a provocative experiment of nature. Bull Univ Minn. 1954; 26: 1-19 Google Scholar The immunodeficiency found in GS typically demonstrates low to absent B cells in the peripheral blood, hypogammaglobulinemia, and defects in cell-mediated immunity in patients 40 to 70 years of age. 2 Stiehm E.R. Ochs H.D. Winkelstein J.A. Immunologic Disorders in Infants & Children. WB Saunders, Philadelphia, PA2004 Google Scholar , 3 Kelleher P. Misbah S.A. Review: What is Good’s syndrome? immunological abnormalities in patients with thymoma. J Clin Pathol. 2003; 56: 12-16 Crossref PubMed Scopus (194) Google Scholar , 4 Joven M.H. Palalay M.P. Sonido C.Y. Case report and literature review on Good's syndrome, a form of acquired immunodeficiency associated with thymomas. Hawaii J Med Public Health. 2013; 72: 56-62 PubMed Google Scholar Infections associated with both B- and T-cell defects are common. [5] Tarr P.E. Sneller M.C. Mechanic L.J. et al. Infections in patients with immunodeficiency with thymoma (Good syndrome): report of 5 cases and review of the literature. Medicine. 2001; 80: 123-133 Crossref PubMed Scopus (197) Google Scholar