Good's syndrome with pulmonary lesions: 3 case reports with literature review

Abstract

Three cases of Good's syndrome with pulmonary lesions in our hospital from June 1, 2010 to June 1, 2013 were retrospective analyzed and relevant literatures were reviewed. Clinical manifestation, characteristics of pulmonary lesions, diagnosis and treatment were summarized. Abnormality of lymphocyte subpopulation to varying degrees in peripheral blood was detected in all 3 cases. However none showed hypogammaglobulinemia. If thymoma patients developed recurrent respiratory infections, Good's syndrome should be considered. Pulmonary manifestations of Good's syndrome have lesions similar to those of diffuse panbronchiolitis or interstitial lung disease. Early screening of immune competency and treatment for immunodeficiency may improve prognosis. Key words: Good's syndrome; Lung diseases