Abstract
The prevalence of obesity and type 2 diabetes mellitus (T2D) continues to rise worldwide. The key features of T2D are altered insulin secretion and peripheral insulin resistance. The insulin responsive glucose transporter, Glut4, facilitates glucose uptake into skeletal muscle, cardiac muscle, and adipocytes. Glut4 has been shown to be downregulated specifically in adipose tissue (AT) but not in muscle in both humans and mouse models with T2D and obesity.1 In this study, Yore et al2 used lipidomics analysis in mice overexpressing Glut4 selectively in AT (AG4OX) to identify a novel class of lipids, the branched fatty acid esters of hydroxyl fatty acids (FAHFAs), with antidiabetic properties. Previous work from this group showed that tissue-specific knockdown of Glut4 in adipocytes caused insulin resistance, whereas overexpression resulted in enhanced glucose tolerance. In addition, the authors previously established that the transcription factor, carbohydrate-responsive element …
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