Abstract
GENERAL COMMENTARY article Front. Behav. Neurosci., 18 August 2011Sec. Learning and Memory https://doi.org/10.3389/fnbeh.2011.00051
Highlights
We published data showing that under some circumstances the effect of protein kinase M zeta (PKMζ) inhibition in the amygdala on the expression of fearpotentiated startle (FPS) is a function of when the drug was applied relative to when testing occurred (Parsons and Davis, 2011)
zeta-pseudosubstrate inhibitory peptide (ZIP) concentration and infusion volume The issue of whether we used a dose of ZIP (10 nmol/μL, 0.5 μl/side) that was inadequate to permanently disrupt fear memory is one that we think will need to be answered with data rather than speculation
We have no reason to believe that the concentration of ZIP we used was inadequate because it has been used successfully to disrupt memory in many other tasks (e.g., Pastalkova et al, 2006) and we replicated the work in several studies using this dose when testing occurred 2 h or a few days after infusion of ZIP (Serrano et al, 2008; Kwapis et al, 2009)
Summary
We published data showing that under some circumstances the effect of protein kinase M zeta (PKMζ) inhibition in the amygdala on the expression of fearpotentiated startle (FPS) is a function of when the drug was applied relative to when testing occurred (Parsons and Davis, 2011).
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