Gonarthrose et chiropratique

Abstract

To compare the effects of different waveforms of 1 MHz and 3 MHz therapeutic ultrasound on endothelial function in healthy subjects.Randomised placebo-controlled, crossover study with concealed allocation and assessor blinding.Imaging Centre of the University Hospital.Thirty volunteers aged between 18 and 35 years were divided into two homogeneous groups (1 MHz and 3 MHz).Continuous (CUT; 0.4 W/cm2SATA), pulsed (PUT; 20% duty cycle, 0.08 W/cm2SATA) and placebo waveforms (equipment off) of ultrasound (1 MHz and 3 MHz) were randomized and applied over the brachial artery for 5 minutes.Endothelial function was evaluated using the flow-mediated dilation (FMD) technique.Both 1 MHz [CUT: mean difference 4%, 95% confidence interval (CI) 2 to 6%, P < 0.001; PUT: mean difference 4%, 95% CI 2 to 6%, P < 0.001] and 3 MHz (CUT: mean difference 4%, 95% CI 2 to 6%, P < 0.001; PUT: mean difference 4%, 95% CI 2 to 6%, P < 0.001) of therapeutic ultrasound increased %FMD by approximately 4% compared with the placebo waveforms. The endothelium-dependent vasodilator responses were the same for both types of waves and frequencies. No differences in baseline diameter, hyperaemic flow, and nitroglycerin-mediated diameter and vasodilation were observed between groups.Both CUT and PUT ultrasound waveforms improved endothelial function. The 1 MHz and 3 MHz frequencies of therapeutic ultrasound led to similar improvement in endothelial function in healthy volunteers.Clinical trial registration number RBR-4z5z3t.