Abstract
Indirect evidence suggests that gonadal steroids and gonadotrophts may have a role in the genesis of epithelial ovarian cancer. In the studies reported herein, we established 17/5estradiol (E2) secreting cell cultures from an omental metastasis of an epithelial ovarian cancer. We demonstrate that human chorionic gonadotropin (hCG), human follicle-stimulating hormone, and epidermal growth factor (EGF’) increased cell growth in a doseand timedependent manner, whereas & inhibited cell growth in the nanomolar range. Epidermal growth factor was able to partially block the negative effect of b; a similar but quantitatively lesser effect was observed with hCG. These results provide direct evidence to support the view that gonadotropins, EGF, TGF/3 (transforming growth factor), and estradiol may modulate growth of metastatic epithelial ovarian cancer cehs. 8 1s~~ fsdeml~ em. IIK.
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