Abstract
Antiandrogen therapy before radiotherapy for definitive treatment of localized prostate adenocarcinoma has become an acceptable neoadjuvant treatment alternative. Huggins first discovered the relationship between androgen deprivation and regression of advanced prostate cancer.' The lack of androgen stimulation on prostatic carcinoma cells initiates the process leading to apoptosis. This process is thought to be synergistic with the effects of ionizing radiation.' Studies have clearly demonstrated that physiological doses of luteinizing hormone (LH)-releasing hormone (RH) analogues mimic LH-RH action, whereas, paradoxically, long-term administration of supraphysiological, pharmacological doses elicits antigonadal effects and regression of hormone dependent prostate tumors.:' We report on a man with prostate cancer whose testosterone did not decrease following treatment with an LH-RH analogue due to the concomitant presence of an asymptomatic functional pituitary adenoma.
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