Abstract
The regulation of ovarian cholesterol storage and depletion was examined in intact immature, hypophysectomized immature and hypophysectomized PMS-HCG treated rats. LH treatment alone caused a depletion of cholesterol in the interstitial tissue of intact animals and stimulated estrogen production, as judged by uterine growth. Neither of these events occurred when LH was given in combination with amino-glutethimide (AGP); instead, cholesterol accumulated in the interstitial tissue. Treatment with LH in the hypophysectomized immature rat resulted in a similar effect, except that no estrogen stimulation of the uterus was noted. Cholesterol failed to accumulate in the corpora lutea of the hypophysectomized PMSHCG treated rats receiving LH alone or LH plus AGP; however, a significant increase in uterine growth occurred with LH treatment alone. Thus, it was concluded that LH alone can cause estrogen production by the corpora lutea, while in the interstitial tissue LH requires some other factor(s) for estrogen pr...
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