Abstract
Cyclic nucleotide concentrations in the oocyte play an essential role in the control of reentry into the cell cycle. Cyclic AMP regulation by the phosphodiesterase PDE3A has been established as critical in the control of oocyte cAMP. Recently, the inhibition of PDE3A by cGMP has provided novel insight linking cGMP and cAMP in the control of oocyte maturation. A role of the NPR2 receptor and its ligand CNP in maintaining cGMP in the follicle and oocyte at levels non-permissive to maturation has been very recently proposed.
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