Abstract
Experimental studies have demonstrated that unilateral testicular castration increases FSH blood levels in infantile animals with contralateral testicular hypertrophy. Prepubertal boys with monorchia show also this contralateral gonadal enlargement being the FSH rol on this mechanism a matter of controversies, in order to clarify this mechanism, 12 prepubertal boys with monorchia were studied. Ages were between 3 and 11 years, all were on Tanner Grade 1 of Puberty, right testis was absent in 8 and left in 4. Scrotal testicular volume was 3 ml in 6 and 4 ml in the other 6. i.v. acute test with 25 ug of Gn-RH was performed and blood was drawn at Basal 20′, 30′ and 60′ post- Gn-RH and serum LH and FSH were measured by RIA. Basal (b) and Maximal increment (Mx) were compared with 9 normal boys, 8 anorchid patients 16 with bilateral cryptorchydism, 4 with unilateral crypt; all were prepubertal, and 21 normal adultmen. Results were as follows (x̄=SD):In summary: On the basis of experimental data which reports increased FSH values followed by testicular hypertrophy after unilateral castration, and that pubertal patients with monorchia have enlarged scrotal testis and they do not increase further until the onset of puberty, it could be assumed that the mechanism of testicular hypertrophy could be induced by pituitary FSH immediately after the atrophy of the crypt, testis with subsequent reduction to normal values.
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