Gonadotropin Alone is a Better Drug for Ovarian Stimulation than in Combination with Clomiphene in Intrauterine Insemination.

Abstract

This study compares the efficacy of sequential clomiphene citrate (CC)+Gonadotropin to that of Gonadotropin alone with ultrasound monitoring. It is a retrospective analytic study done on a total of 100 couples to compare two groups receiving CC+Gonadotropin and Gonadotropin alone for ovarian stimulation followed by intrauterine Insemination (IUI). We studied the cycle performance parameters. Cumulative pregnancy rates and ovulation rates were the primary outcomes. Results were analyzed following the intention-to-treat principle. There were no significant differences with respect to indications and the numbers of dominant follicles recruited. The endometrial thickness was significantly better in Gonadotropin-alone group (P<0.05). Ovulation rate was better for CC+Gonadotropin at 95.91%. Nine pregnancies were in the CC+Gonadotropin group (18.36%) and 17 in Gonadotropin-alone group (33.3%). Significant differences in pregnancy rates and endometrial thickness were seen. Gonadotropin alone thus appears to give better results, but CC+Gonadotropin seems to be a cost-effective drug.