Abstract
CLINICIANS HAVE LONG LOOKED to the laboratory for aid in objectively differentiating and classifying, the various endocrinopathies involving the pituitary gland and the gonads. After the reliability of the Aschheim-Zondek and Friedman tests for pregnancy was established, it was hoped that gonadotropic assays of urine and blood would yield similar aid in diagnosis of gonadal dysfunctions. But the first prerequisite of any biological test proposed as a diagnostic and therapeutic aid in dysfunctional states is a thorough understanding of the range of values encountered in the normal individual. Since the research laboratories unfortunately have not supplied this prerequisite for normal gonadotropins, the clinician has been disappointed. Two conditions must be met in order to provide the clinician a useful diagnostic tool. The first is that methods be sufficiently quantitative and sensitive to determine the normal levels of hormone excretion. The second is that the characteristics of the normal range be suffi...
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