Gonadoblastoma associated with mixed gonadal dysgenesis

Abstract

This article reports the case of a virilized 15-year-old Iranian girl with mixed gonadal dysgenesis and a gonadoblastoma of the left abdominal testis; the karyotype was 46/XY. This tumor is the eleventh recorded example of a gonadoblastoma demonstrated to arise in a patient with mixed gonadal dysgenesis. Although the Leydig or lutein cells of gonadoblastomas have been shown to be responsible for virilization in other cases, the Leydig cells of the uninvolved portion of the testis were the probable source of androgen in this patient.