Gold versus platinum for chemical modification of carbon quantum dots from carboxymethyl cellulose: Tunable biomedical performance

Abstract

Urgent requirements for medication from chronic inflammation and cancer are considerably interested, while, the recent reports were considered with investigating simple methods for synthesis. Metal-modified carbon quantum dots (“M-CQDs”) were successfully ingrained from carboxymethyl cellulose under the assistance of infra-red irradiation. The current approach demonstrates a study for the effect of structural tuning for biomedical performance of CQDs via modifying of CQDs with either gold (Au-CQDs) or platinum (Pt-CQDs). Successive nucleation of Au-CQDs and Pt-CQDs was confirmed via different instrumental analyses like, TEM micrographs, Zeta potential, XRD, FTIR, 1HNMR&13CNMR spectra. The data reveal that, modification of CQDs (8.7 nm) with gold was reflected in insignificant effect on the mean size of CQDs (8.9 nm), whereas, doping of platinum resulted in slight enlargement of the size (12.4 nm). However, Pt-CQDs were exhibited with the highest anti-inflammatory (cell viability percent 78 %) and antimicrobial action. On the other hand, Au-CQDs were shown with the highest anticancer affinity (reduction of cell viability 83 %) compared to the others. The current study approved the superiority of CQDs modified with either gold or platinum to be successfully applicable as potential therapeutic reagents for the treatment of either cancer or inflammation diseases.