Abstract
A novel cotton thread immunochromatographic assay device was successfully developed based on gold nanoparticles decorated carbon nanotube nanocomposite probe (CNT/GNPs). Squamous cell carcinoma antigen (SCCA), a protein biomarker related to lung cancer, was used as an analyte to demonstrate the principle of immunochromatograpgic assay on cotton thread biosensor. Results indicated that CNT/GNPs exhibited good stability and superior sensitivity comparing with individual carbon nanotubes as reporter probe. Under optimal conditions, the biosensor was capable of measuring 3.03ng/mL SCCA which is 10 and 5000 folds more sensitive than previous reported CNT based lateral flow assay. The combination of CNT/GNPs nanocomposite probe with cotton thread based biosensor provide an alternative path for clinical diagnosis of other protein or nucleic acid biomarkers.
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