Abstract
Recent advances in the preparation and characterization of metal core-based nanoparticles have opened the way to their exploration as carriers for carbohydrate-based vaccines. Here we describe the protocols for the preparation and characterization of water dispersible gold nanoparticles (1-3 nm gold diameter) as carriers for carbohydrate antigens. We mainly refer to the protocols we used for the preparation of gold glyconanoparticles as carrier for an S. pneumoniae carbohydrate-antigen. The high number of ligands at the gold nanoparticles surface and the easiness of their one-pot preparation make these biocompatible nanomaterials an attractive tool for glyco-scientists.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have