Abstract
Surface acoustic wave (SAW) biosensors possess advantages of high efficiency, low cost and label free detection, and have potential applications in clinical diagnostics. However, it is a great challenge for SAW biosensors to detect small concentrations of biomarkers in clinical sample. Nanomaterials have been widely used in bioanalysis techniques to fabricate highly sensitive biosensors. In this paper, a SiO 2 guided SAW biosensor was developed for immunodetection. Rabbit IgG was utilized as the capture probe to specifically recognize the target goat anti-rabbit IgG. Gold nanoparticles (AuNPs) were modified with goat anti-rabbit IgG to form nanoprobes for competitive immunoassay. Combining a SAW biosensor with gold nanoprobes, a low detection limit in the pg/mL level was achieved, enabling applications to early diagnosis of diseases.
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