Abstract
Gold nanoparticles (GNPs) possess a number of useful characteristics that have catapulted them into the mainstream of cancer research. Their optical properties enable them to be used in photodynamic and photothermal therapy as well as contrast agents in photoacoustic imaging. In addition, the ability to bind ligands to the GNP surface has made them valuable bio-markeraware drug carriers. But the effectiveness of any cancer fighting tool relies on homogenous distribution and penetration throughout the tumor, and the uptake and transport dynamics of GNPs has previously been held to monolayer cell models. In this work, multicellular layers (MCLs) are used as a solid tumor model to measure the penetration and uptake of GNPs in tumor tissue. MCLs offer a unique way to bridge the gap between in vitro single-layer cell models and the in vivo tumor. The effects of increased cell-to-cell connections, extracellular matrix and tumor characteristics are investigated to deliver new insights into the transport of GNPs in tissue.
Highlights
Elucidating the Uptake and Distribution of Nanoparticles in Solid Tumors via a Multilayered Cell Culture Model respectively
possess a number of useful characteristics that have catapulted them into the mainstream of cancer research
the effectiveness of any cancer fighting tool relies on homogenous distribution and penetration throughout the tumor
Summary
Elucidating the Uptake and Distribution of Nanoparticles in Solid Tumors via a Multilayered Cell Culture Model respectively. Cell population doubling times for MCF-7 and MDAMB-231 monolayer cell cultures were 38.83 and 37.10 hrs, respectively. Cell population doubling times for MCF-7 and MDA-MB-231 multilayer cell cultures were 48.36 and 51.07 hrs, respectively. Gold nanostructures are being used as a therapeutic agent in radiation therapy (RT), chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT). These new opportunities encourage innovations leading to effective combinational therapy in the fight against cancer[2].the success of such innovations relies on GNP distribution and penetration throughout the tumor. We used multicellular layers (MCLs) to mimic tumor tissue to study the penetration and uptake of GNPs in a tumor-like microenvironment
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