Abstract
In recent years, tremendous efforts have been devoted into the fields of valuable diagnosis and anticancer treatment, such as real-time imaging, photothermal, and photodynamic therapy, and drug delivery. As promising nanocarriers, gold nanomaterials have attracted widespread attention during the last two decades for cancer diagnosis and therapy due to their prominent properties. With the development of nanoscience and nanotechnology, the fascinating bio-applications of functionalized gold nanomaterials have been gradually developed from in vitro to in vivo. This mini-review emphasizes some recent advances of photothermal imaging (PTI), surface-enhanced Raman scattering (SERS) imaging, and photoacoustic imaging (PAI)-guided based on gold nanomaterials in vivo therapy in near infrared region (>800 nm). We focus on the fundamental strategies, characteristics of bio-imaging modalities involving the advantages of multiples imaging modalities for cancer treatment, and then highlight a few examples of each techniques. Finally, we discuss the perspectives and challenges in gold nanomaterial-based cancer therapy.
Highlights
Because of the high incidence and mortality of cancer, scientists have paid long term attention to the diagnosis and treatment of cancer
Different types of functionalized gold nanosensors have been reported with the development of the surface modification
The multifunctional gold nanomaterials have been showed for imaging-guided in vivo cancer therapy using photothermal, surface-enhanced Raman scattering (SERS), photoacoustic imaging (PAI), and multiples imaging modalities
Summary
Because of the high incidence and mortality of cancer, scientists have paid long term attention to the diagnosis and treatment of cancer. The photothermal imaging (PTI), surface-enhanced Raman scattering (SERS), and photoacoustic imaging (PAI) guided in vivo cancer therapy are focused. Gold nanomaterials are considered as exogenous photothermal transduction agents for PTI and contrast agents for PAI, which can accumulate at tumor tissue via the enhanced permeability and retention (EPR) effect (Henry et al, 2016).
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