Abstract
The development of novel ligands specifically tailored for homogeneous gold catalysis permits the development of new gold catalysis. In this work, we report that a remotely functionalized biphenyl-2-ylphosphine ligand enables gold-catalyzed cyclization of homopropargylic alcohols accompanied by an unusual silyl migration, which provides efficient access to 3-silyl-4,5-dihydrofurans. DFT studies of the mechanism of this novel transformation suggest the synergy between the steric bulk of the ligand and its properly positioned remote tertiary amino group in facilitating a concerted silyl migration and cyclative C-O bond formation step.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
