Gold-catalyzed formal (3 + 2) and (4 + 2) cycloaddition reactions using propiolates: assembly of 2,3-dihydrofurans and 3,4-dihydropyrans via a multistep cascade process

Abstract

A gold-catalyzed formal dipolar cycloaddition reaction was developed using polarized alkynes as dipolarophiles and butenediol or pentenediol derivatives as formal dipoles. Silyl groups were used to solve the selectivity issue of unsymmetrical diols.