Going horizontal: spatiotemporal dynamics of evoked activity in rat V1 after retinal lesion.

Abstract

Event Abstract Back to Event Going horizontal: spatiotemporal dynamics of evoked activity in rat V1 after retinal lesion. Ganna Palagina1*, Ulf T. Eysel2 and Dirk Jancke3 1 Ruhr-Universitat, Institute of Neuroinformatics, Germany 2 Ruhr-Universitat, Department of Neurophysiology, Germany 3 Ruhr-Universitat, Bernstein Group for Computational Neuroscience, Germany Sensory deprivation caused by peripheral injury can trigger functional cortical reorganization across the initially silenced cortical area (lesion projection zone). It is proposed that long-range intracortical connectivity enables recovery of function in the lesion projection zone (LPZ) , providing a bypass for the lost subcortical input. Here we investigated retinal lesion-induced changes in the function of lateral connections in the primary visual cortex of the adult rat. Using voltage-sensitive dye imaging, we visualized in millisecond time resolution spreading synaptic activity across the LPZ. Briefly after lesion, the majority of neurons within the LPZ were subthresholdly activated by delayed propagation of activity that originated from unaffected cortical regions. With longer recovery time latencies within the LPZ gradually decreased and activation reached suprathreshold levels. Shortening of latencies of horizontal spread and increase in amplitudes of activity inside the LPZ during reorganization support the idea, that increase in strength of lateral connections is a substrate of functional recovery after retinal lesions. Conference: Bernstein Conference on Computational Neuroscience, Frankfurt am Main, Germany, 30 Sep - 2 Oct, 2009. Presentation Type: Poster Presentation Topic: Learning and plasticity Citation: Palagina G, Eysel UT and Jancke D (2009). Going horizontal: spatiotemporal dynamics of evoked activity in rat V1 after retinal lesion.. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference on Computational Neuroscience. doi: 10.3389/conf.neuro.10.2009.14.128 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Aug 2009; Published Online: 27 Aug 2009. * Correspondence: Ganna Palagina, Ruhr-Universitat, Institute of Neuroinformatics, Bochum, Germany, anna.palagina@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ganna Palagina Ulf T Eysel Dirk Jancke Google Ganna Palagina Ulf T Eysel Dirk Jancke Google Scholar Ganna Palagina Ulf T Eysel Dirk Jancke PubMed Ganna Palagina Ulf T Eysel Dirk Jancke Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.