Goal-directed action anticipation and prediction error processing in children with autism spectrum disorders: An eye-movement study

Abstract

BackgroundDifferences in predictive ability have been proposed as a possible explanation for the core symptoms of autism spectrum disorder (ASD). This study aimed to investigate potential differences in prior knowledge acquisition and application for goal-directed anticipation in children with ASD. MethodThe study included 22 children with ASD and 19 typically developing (TD) children between the ages of 5–10 years. Two eye-tracking phases were used to examine the formation of goal-directed action anticipations and the processing of action prediction errors. In the action anticipation formation phase, participants were asked to observe goal-directed actions repeatedly to examine prior knowledge acquisition about agent-goal association. In the action anticipation violation phase, the goals of actions were changed to examine the application of previously acquired knowledge. ResultsChildren with ASD required more trials to form goal-directed anticipations than TD children. Furthermore, prior knowledge acquisition was characterized by variability and instability in children with ASD. During the action anticipation violation phase, children with ASD exhibited lower preference for the action goal determined by prior knowledge in uncertain situations. This atypical processing of prior knowledge was significantly correlated with the severity of ASD symptoms. ConclusionsOur findings support the Bayesian perception theory and predictive coding theory, suggesting that children with ASD may experience difficulties in both the acquisition and application of prior knowledge in anticipation. These findings have implications for developing interventions to improve goal-directed anticipation and reduce social and communication difficulties in individuals with ASD.