GO/CaCO3/SiO2 nanocomposite incorporated Carrageenan/Chitosan injectable hydrogel for enhanced hemostasis

Abstract

Every year, millions of civilian casualties are caused by excessive bleeding, often known as hemorrhage. Even if the initial bleeding is effectively controlled, wound sequelae such as infection remains a substantial cause for persistent morbidity. Numerous blood clotting materials have been found, tried, and used to stop the bleeding. Topical dressings such gauzes, as well as organic and bioinspired materials are used to stop bleeding. None of these substances, however, can accurately duplicate the intricate and dynamic characteristics of blood clotting and the body's natural ability for wound healing. In this research work we have synthesized GO/CaCO3/SiO2 nanocomposite and incorporated them in a polymeric hydrogel for blood clotting application. The nanocomposite is characterized with XRD, FTIR and TEM. The injectable hydrogel is characterized with FTIR and SEM. Colony count and growth curve analysis are done for the nanocomposite. The injectable hydrogel consisting of the GO/CaCO3/SiO2 nanocomposite enhances the blood clotting property. This hydrogels with graphene oxide nanocomposite will be an ideal choice for addressing the clear need for better blood clotting material.