Abstract
GnRH agonists or antagonists can be used to prevent LH surges duringovarian stimulation for assisted reproduction. GnRH agonists down-regulate GnRH pituitary receptors. GnRH antagonists directly andrapidly inhibit gonadotrophin release. In a 2006 systematic review invol-ving 29 trials, the average clinical pregnancy rate was 4.7% lower withGnRH antagonist treatment and the incidence of ovarian hyperstimula-tion syndrome (OHSS) was 2% lower compared with GnRH agonisttreatment (Al-Inany et al.,2006). The current update includes 45trials which addressed live birth or ongoing pregnancy rate (OPR) inGnRH antagonist and GnRH agonist protocols among women under-going assisted reproduction treatment (Youssef et al.,2011).
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