Glyphosate on shikimic acid on Urochloa plantaginea

Sydnei Dionisio Batista De Almeida,Sonia Claudia Do Nascimento De Queiroz,Marcus Barifouse Matallo,Antonio Luiz Cerdeira,Daniel Andrade De Siqueira Franco

doi:10.1590/0103-8478cr20190825

Sydnei Dionisio Batista De Almeida, Sonia Claudia Do Nascimento De Queiroz + Show 3 more

Open Access

https://doi.org/10.1590/0103-8478cr20190825

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Journal: Ciência Rural	Publication Date: Jan 1, 2020
License type: CC BY 4.0

Affiliation: Instituto Biológico

Abstract

ABSTRACT: Shikimic acid (SA) has witnessed a strong increase in recent years due to the increasing demand of the pharmaceutical and cosmetic industry. The SA is used as a precursor for the synthesis of oseltamivir phosphate (Tamiflu®), a potent viral inhibitor and is extracted from the plant Illicium verum Hook which has a limited availability. This article proposed the use of Urochloa plantaginea (Link.) webster and glyphosate, as an alternative source of SA. U. plantaginea plants with 3 - 4 tillers and 4 - 6 leaves were harvest at 3, 6, 9 and 12 days after application (DAT) of low rates of glyphosate. Samples were dried, extracted, analyzed by HPLC and LC-MS/MS. The maximum SA concentrations were observed at 6 days after glyphosate at 36 g.a.e.ha-1 was applied in plants of U. plantaginea with 4 to 6 leaves. The capability of this annual gramineae to produce elevated SA levels throughout the entire biomass affords its potential for a greater yield on a per hectare basis.

Highlights

Shikimic acid (SA) has witnessed a strong demand in recent years due to the increasing use in the pharmaceutical and cosmetic industry as a chiral binding block for the synthesis of a wide range of products (QUIROZ et al, 2014)
The SA is used as a precursor for the synthesis of oseltamivir phosphate (Tamiflu®), a potent viral inhibitor and is extracted from the plant Illicium verum Hook which has a limited availability
The maximum SA concentrations were observed at 6 days after glyphosate at 36 g.a.e.ha-1 was applied in plants of U. plantaginea with 4 to 6 leaves

Summary

Introduction

Shikimic acid (SA) has witnessed a strong demand in recent years due to the increasing use in the pharmaceutical and cosmetic industry as a chiral binding block for the synthesis of a wide range of products (QUIROZ et al, 2014). The focus on SA has increased in recent years due to the increasing number of flu victims worldwide (BORAH, 2015). The increased demand for oseltamivir phosphate from the agricultural sector is the key factor in boosting demand for SA for the coming years. This acid is mainly extracted from the plant I. verum, and the limited availability of this plant is expected to prevent market growth in the near future (FARINA & BROWN, 2006). The SA content in the plants varies according to the vegetable source and the harvest season and other factors (GHOSH et al, 2012)

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