Abstract
The treatment of Parkinson's disease and depression is still far from satisfactory. The objective of the present study was to evaluate the potential of methanolic extract of Glycyrrhiza glabra (GGE) as an adjuvant in treatment of Parkinson's disease and depression. In acute study GGE (30 and 100mg/kg i.p.) significantly inhibited haloperidol-induced catalepsy in mice in dose dependent manner. Similar inhibitory effect of GGE was also observed in chronic study (15 days) indicating that there was no development of tolerance. The GGE reduced duration of catalepsy also. In mice treated with GGE (30mg/kg i.p.) for 6 days and given haloperidol on 7th day showed significantly (P<0.05) diminished catalepsy and the higher dose completely inhibited catalepsy. This indicated its ability to retain the anticataleptic effect. Further GGE in both the doses increased apomorphine-induced sniffing indicating stimulation of Dopamine D1 receptor stimulation.
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