Abstract
The focus of this work was to prepare Spanish Broom, flax, and hemp dressings impregnated with glycyrrhetinic acid (GA) liposomes or hyalurosomes to promote the healing process and protect the skin wounds. Vesicles were prepared by the film hydration method and characterized in terms of size, particle size distribution, ζ potential, encapsulation efficiency, in vitro release, and biocompatibility on 3T3 fibroblasts. Loaded liposomes and hyalurosomes showed nanometric size (355 ± 19 nm and 424 ± 32 nm, respectively), good size distribution (lower than 0.3), and appropriate encapsulation efficiency (58.62 ± 3.25% and 59.22 ± 8.18%, respectively). Hyalurosomes showed good stability during the storage period, which can be correlated to the negative ζ potential, and allowed a fast and complete release of GA. Preliminary biological studies revealed that both kinds of loaded vesicles were not cytotoxic and that hyalurosomes could exert a slight stimulating effect on fibroblast proliferation. Finally, in vitro release studies from the different dressings impregnated with the loaded vesicles demonstrated that a high amount of GA could be reached at the wound site after 60 min from application. In conclusion, the results suggested that the developed dressings, especially those impregnated with hyalurosomes, can be efficiently used to promote the healing process.
Highlights
In recent years, the focus of wound-care has been based on research and development of new antibacterial and anti-inflammatory wound dressings able to improve and accelerate the healing process
The aim of this study was the development of new Spanish Broom, flax, and hemp wound dressings impregnated with nanosystems containing 18-β-glycyrrhetinic acid (GA) for wound healing management
GA-loaded liposomes and hyalurosomes were prepared through the film hydration method followed by extrusion and subsequently sunk into Spanish Broom, flax, or hemp gauzes, by impregnation
Summary
The focus of wound-care has been based on research and development of new antibacterial and anti-inflammatory wound dressings able to improve and accelerate the healing process. Traditional wound dressings are textile fibers such as cotton, wool, and silk, but new wound dressing materials are an important part of the rapidly growing biomaterials industry [5]. In this regard, the aim of this study was the development of new Spanish Broom, flax, and hemp wound dressings impregnated with nanosystems containing 18-β-glycyrrhetinic acid (GA) for wound healing management.
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