Abstract
OPINION article Front. Microbiol., 16 November 2016Sec. Microbiotechnology Volume 7 - 2016 | https://doi.org/10.3389/fmicb.2016.01849
Highlights
Specialty section: This article was submitted to Microbiotechnology, Ecotoxicology and Bioremediation, a section of the journal Frontiers in Microbiology
Advances in biotechnological tools in systems and synthetic biology, chemical biology and metabolic engineering, genome sequencing, and synthesis, protein engineering and mutagenesis have enabled alteration of the biological routes of natural product (NP) biosynthesis in heterologous robust hosts to produce a wide array of compounds (Pandey et al, 2016), adding diversity in the NPs
When mycosamine sugar was replaced by perosamine in amphotericin B, antifungal and hemolytic activities were improved in new derivative which has minimal inhibitory activity concentration (MIC) of 1.9 μg/ml compared to 2.1 μg/ml of amphotericin B against Saccharomyces cerevisiae (Hutchinson et al, 2010)
Summary
Specialty section: This article was submitted to Microbiotechnology, Ecotoxicology and Bioremediation, a section of the journal Frontiers in Microbiology. Advances in biotechnological tools in systems and synthetic biology, chemical biology and metabolic engineering, genome sequencing, and synthesis, protein engineering and mutagenesis have enabled alteration of the biological routes of natural product (NP) biosynthesis in heterologous robust hosts to produce a wide array of compounds (Pandey et al, 2016), adding diversity in the NPs. Post-modifications of NPs by tailoring enzymes is one of the promising approaches for engineering and manipulating NPs under human control with selective power. Such powerful enzymes can be engaged for the exchange of diverse sugar moieties using microbial cells engineered to produce secondary metabolites using metabolic engineering tools.
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