Abstract
Glycosylation represents a major posttranslational modification reaction of proteins and plays a pivotal role in a variety of cellular events. N-Acetylglucosaminyltransferases III (GnT-III) and V (GnT-V), and α 1-6 fucosyltransferase are key enzymes in the processing of N-linked glycoproteins, and are heavily involved in cancer progression and metastasis. Very recently we also found that GnT-III is capable of reducing or masking the expression of the αGal epitope, which is a major xenoantigen in swine to human xenotransplantation. In this minireview we focus on the role of the above glycosyltransferases in cancer metastasis as well as in xenotransplantation.
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