Abstract
Objective To examine the expression of hypoxia-inducible factor-1α (HIF-1α), TfR1, and TfR1-attached terminal monosaccharides in placentas of women with IDAP and severe preeclampsia. Methods TfR1 and HIF-1α were detected by western blot. Immunoadsorption of TfR1 was performed to characterize the terminal monosaccharides by specific lectin binding. Results There was no difference in the expression of TfR1 and HIF-1α between groups. Lectin blot analysis pointed out an overexpression of galactose β1-4 N-acetylglucosamine (Gal-GlcNAc) and mannose in severe preeclampsia. Conclusion The increase in Gal-GlcNAc may be due to the increased presence of antennary structures and the mannose glycans of TfR1 may indicate the presence of misfolded or incomplete proteins. These findings may be associated with the low expression of placental TfR1 in women with preeclampsia.
Highlights
IntroductionIron deficiency anemia in pregnancy (IDAP) is diagnosed by a low hemoglobin concentration (
Iron is an essential nutrient for metabolic processes [1]
Women with IDAP showed both lower ferritin (P = 0.0026) and hemoglobin values (P = 0.0060) and the group of women with preeclampsia showed the highest values in systolic and diastolic blood pressure (P = 0.0047 and P = 0.0036)
Summary
Iron deficiency anemia in pregnancy (IDAP) is diagnosed by a low hemoglobin concentration (
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