Abstract
This historical development, biosynthesis, analysis, interpretation, and utilization of glycosylated hemoglobin determinations (HbA1 or HbA1c alone) are presented. The relationship between glycosylated hemoglobin determinations and assessment of diabetic control is discussed. HbA1 and HbA1c levels are elevated approximately twofold in diabetic patients. A correlation exists between abnormal fluctuations in blood glucose levels and HbA1 concentrations. The results of glycosylated hemoglobin determinations are not influenced by recent meals, physical activity, emotional stress, or inherited abnormalities. Although glycosylated hemoglobin determinations are subject to fewer variables than blood and urine glucose assessments, the clinician must be aware of the indications and limitations for their use. These indications and limitations are discussed.
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