Abstract
PurposeTo evaluate the performance of first trimester maternal serum glycosylated (Sambucus nigra lectin-reactive) fibronectin in prediction of gestational diabetes mellitus (GDM).MethodsIn this case–control study, first trimester maternal serum glycosylated fibronectin and fibronectin were measured in 19 women who consequently developed GDM and in 59 control women with normal pregnancy outcomes. Adiponectin was used as a reference protein to evaluate relation of glycoprotein to SNA-lectin-reactive assay format. Samples were taken during gestational weeks 9+6–11+6. Data concerning GDM was obtained from the National Institute for Health and Welfare, which records the pregnancy outcomes of all women in Finland.ResultsThere was no difference in maternal serum glycosylated fibronectin concentrations between women with consequent GDM [447.5 μg/mL, interquartile range (IQR) 254.4–540.9 μg/mL] and control women (437.6 μg/mL, IQR 357.1–569.1 μg/mL). Maternal serum fibronectin levels were significantly lower in GDM group (224.2 μg/mL, IQR 156.8–270.6 μg/mL), compared to the control group (264.8 μg/mL, IQR 224.6–330.6 μg/mL, p < 0.01). There was no difference in assay formats for adiponectin.ConclusionThere was no association between first trimester maternal serum glycosylated (SNA-reactive) fibronectin and GDM.
Highlights
Gestational diabetes mellitus (GDM) is a growing risk for both maternal and fetal health as its prevalence is increasing worldwide
Increasing prevalence is worrisome as the adverse effects of GDM are not confined to pregnancy since it can affect the later health of both mothers and children [2, 3]
There were no significant differences in gestational age at sampling, maternal weight or smoking habits
Summary
Gestational diabetes mellitus (GDM) is a growing risk for both maternal and fetal health as its prevalence is increasing worldwide. In Finland, the prevalence of GDM was 15.6% in 2017 and 14.1% of women were obese [body mass index (BMI) ≥ 30 kg/m2] before pregnancy [1]. Increasing prevalence is worrisome as the adverse effects of GDM are not confined to pregnancy since it can affect the later health of both mothers and children [2, 3]. Healthy lifestyle changes in diet and exercise can reduce the risk of GDM and the effect is stronger the earlier the intervention is made [4]. There is a need for an effective first trimester screening method for GDM to enable robust intervention
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
