Abstract
Severe hyperglycæmia developed in two patients with functioning kidney transplants. This prompted the detection of glycosuria in seventeen of thirty-one patients with functioning kidney grafts. Oral glucose-tolerance tests were carried out on seventeen patients with glycosuria or a family history of diabetes and in four patients without either. In twelve of these patients glucose tolerance was abnormal. Glycosuria and glucose intolerance were usually, but not invariably, first detected within 3 months of kidney transplantation, and often, but again not invariably, after increasing the dose of immunosuppressive drugs in rejection episodes. The fasting plasma-insulin level was normal in all twelve patients tested. However, in all patients the insulin response to oral glucose was abnormally low, whether the glucose-tolerance curve was abnormal or not.
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