Abstract
Purpose: Many SF studies have focused on the lubricity and wear protection properties of isolated components, such as lubricin, hyaluronan, or lipids. Higher-order mixtures studies, such as hyaluronan and lubricin, hyaluronan and phospholipids, lubricin and galectins, or hyaluronan and aggrecans, combined with a top-down approach in which different components have been enzymatically digested, emphasize that it is the synergistic interactions that provide SF's unique load-bearing, wear protecting, and lubricating.
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