Abstract
Possibilities of synchronized oscillations in glycolysis mediated by various extracellular metabolites are investigated theoretically using two-dimensional reaction-diffusion systems, which originate from the existing seven-variable model. Our simulation results indicate the existence of alternative mediators such as ATP and 1,3-bisphosphoglycerate, in addition to already known acetaldehyde or pyruvate. Further, it is also suggested that the alternative intercellular communicator plays a more important role in the respect that these can synchronize oscillations instantaneously not only with difference phases but also with different periods. Relations between intercellular coupling and synchronization mechanisms are also analyzed and discussed by changing the values of parameters such as the diffusion coefficient and the cell density that can reflect in tercellular coupling strength.
Highlights
Synchronization in biological systems is widely observed in the natural world
1) Glycolytic oscillations with different phases can be synchronized by means of intercellular coupling via such substances as S4, A3, S3 and S2, as demonstrated in Models I, II, III and IV
Synchronization of oscillations with different periods can be mediated by intercellular coupling substances such as A3, S3 and S2, as demonstrated in Models II, III and IV. The latter synchronization is characterized by speedy convergence to the synchronous oscillatory state
Summary
Synchronization in biological systems is widely observed in the natural world. This phenomenon is one of the collective behaviors thought to have a crucial role in maintaining the individual life or in giving benefits for communities. (2014) Glycolytic Synchronization in Yeast Cells via ATP and Other Metabolites: Mathematical Analyses by Two-Dimensional Reaction-Diffusion Models. Glycolysis is a biological mechanism to decompose glucose and to store energy in the form of ATP. In this chemical process, synchronized variations can be seen for the concentrations of various metabolites [3]-[8]. Yeast cells exhibit glycolytic synchronized oscillations under certain conditions. The emergence of the collective behavior such as synchronization may occur above a critical cell density
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