Abstract
We highlight recently discovered glycolytic oscillations in HeLa cervical and DU145 prostate cancer cells, and discuss the individual and collective behaviors based on a mathematical model proposed previously. We found strong heterogeneities in the oscillations, indicating that glycolytic enzymatic activities are very heterogeneous in these cells. Further, the degree of synchronisation in their oscillations was very low, indicating that cell-to-cell interaction is very low during glycolysis in cancer cells. Biomedical implications obtained from the analyses of the oscillatory dynamics are also presented; more malignant cancer cells tend to exhibit glycolytic oscillations with higher frequencies than less malignant cells. Thus, glycolytic oscillations in cancer cells can be a medical indicator to detect the malignancy of cancer cells.
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