Abstract
Immunometabolism determines the fate and function of regulatory T cells. The metabolic phenotype of regulatory T cells (Treg) is affected by various factors. The relationship between Treg metabolism and function of mice with sepsis is not clear. We used liquid chromatography and tandem mass spectrometry (LC-MS/MS) to analyze the metabolic profiles of freshly-isolated spleen Treg cells in mice with sepsis. It was found that in severe infection, activated Treg cells depend on glycolysis and fatty acid oxidation, and inhibition of metabolic pathways has a significant impact on the number and quality of Treg cells. Understanding the metabolic characteristics of Treg cells in the real environment in the body helps to grasp the function of Treg cells and even the overall immune status. Targeting the metabolic pathway of Treg may provide a new method for the treatment of sepsis.
Highlights
Sepsis is a disease caused by an excessive immune response against the pathogen
We found that the metabolic phenotype of sepsis Treg cells and the control group was different, and activated Treg cells have increased glycolysis and fatty acid oxidation (FAO)
It is generally believed that immunosuppression in the later stages of sepsis is related to the loss of effector T cells and the upregulation of Treg cells
Summary
Many studies have shown that hyperactivated innate immunity and immune-suppression occur simultaneously in sepsis. This immune disorder usually results in poor prognosis.[1,2,3] Patients who survive an episode of sepsis o en develop a long-lasting stage of immunosuppression making them susceptible to certain secondary infections.[4,5,6] This immunosuppression is usually characterized by lymphopenia (T cell decline is most pronounced) and loss of immune function.[7,8] The regulatory T cells are major immunoregulatory cells. Immunometabolism determines the fate of T cells and their immunological function under various pathological conditions including cancers, infections and autoimmune diseases.[16,17,18,19,20] studying the metabolism and function of immune cells under severe infection will be of great signi cance for
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