Glycolysis intensity and activities of energy metabolism enzymes in the rat brain during repeated exposure to hypoglycemic doses of insulin

Abstract

Renewable conditions of hypoglycemia are a frequent complication in the treatment of diabetes mellitus, determine the clinic of pancreatic insulinomas, are observed in diseases of the kidneys, liver, gastrointestinal tract and alcoholism, leading to the development of posthypoglycemic encephalopathy. At the same time, a single, even severe, insulin coma is accompanied by reversible metabolic changes in the brain.
 Therefore, the pathological features of metabolism in the nervous tissue, which are the result of repeated hypoglycemia, in particular possible disturbances in energy metabolism, require further study.
 In this work, we studied the main ways of glucose metabolism - the intensity of glycolysis and glycogenolysis, the activity of Krebs cycle dehydrogenases, alanine and aspartate aminotransferases in the rat brain in setting of multiple hypoglycemia.