Abstract
Phosphoinositol 4-phosphate adaptor protein-2 (FAPP2) transports glucosylceramide from its cytosol-facing, synthetic site in the cis-Golgi, enabling conversion into complex glycosphingolipids. Glucosylceramide transfer occurs via the FAPP2 C-terminal region which shares moderate sequence homology with human glycolipid transfer protein (GLTP), a unique conformational fold that defines the GLTP superfamily. Herein, GLTP-fold formation by FAPP2-GLTP, its transfer specificity for glycolipids, and its biophysical properties have been investigated.
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